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Christina V. Kenneth Kee. Bladder Pain Syndrome. Critically appraise issues of missing data and imputation methods e. To assess statistical heterogeneity in effects between studies, we will calculate the chi-squared statistic and the I 2 statistic the proportion of variation in study estimates attributable to heterogeneity rather than due to chance [ 41 , 42 ].

For the chi-squared statistic, we will adopt a p value of 0.

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In cases of high heterogeneity, we will explore potential reasons for heterogeneity. If we encounter high unexplained heterogeneity, we will not perform any quantitative syntheses. We will exclude non-randomized studies with high risk of bias or studies that are unadjusted for potential confounders for our data synthesis, but we will include them for sensitivity analyses. We do not plan any subgroup analyses as part of the general data analyses.